Reverse Vaccinology Approach for the Prevention of Mycobacterial Diseases in Cattle


Photo of cowInfectious diseases continue to be a leading cause of sickness and death in domestic animals and are of significant concern to human health due to their potential to be transferred to people.

Direct economic losses to livestock producers are large, but these are dwarfed by the losses associated with international trade restrictions as has been seen in Canada with mad cow disease, influenza and other diseases.


Utilize Reverse Vaccinology and guidance from GE3LS studies to create new vaccines and companion diagnostics for Johne’s disease and bovine tuberculosis. These two most costly and recalcitrant diseases affecting livestock producers in Canada and worldwide.


We propose to use a genomics-based approach termed reverse vaccinology, by identifying and pursuing in parallel every possible candidate protein as a potential vaccine for important diseases of cattle, including Johne’s Disease and bovine tuberculosis.


The team’s work will ultimately increase productivity and profitability for cattle producers and increase public confidence by reducing the use of slaughter or antibiotics to control infections. It will also enhance Canada’s reputation as a major Agrifood producer. The annual financial impact of the vaccines is estimated to be around $100 million, with international sales of a further $400 million.


The project value is $7.4 million funded from Genome Canada, VIDO-InterVac and Genome British Columbia.